If you have a real period, there will be bright red blood coming out of the vagina, so you should not use vaginal plugs. If the inflammation of the vagina is serious or the itching is obvious, you can wash the vulva with cleansing medication or clean the vulva with water, or you can change the oral medication. It is generally recommended to use vaginal plugs after 2-3 days of complete menstruation. Otherwise, if you use vaginal plugs during menstruation, the plugs will easily flush out the medication and lead to retrograde infection. If the bleeding is only a little bit, but not during menstruation, you can use vaginal plugs at this time.