Children with small blisters on the hands, clinically known as blisters, may be caused by ringworm, sweat herpes and other factors, can be treated by topical drugs or oral medication and other ways. 1. Ringworm: it is a skin infection of the hands caused by dermatophytes, clinically manifested as localized blisters and flaking production. It can be treated with topical ketoconazole, miconazole and other antifungal drugs, and oral itraconazole and other drugs for severe cases. 2. Sweat herpes: is a symmetrical distribution of blistering skin disease, may be localized contact with certain allergic substances caused by, preferably in the hands and feet. Clinical manifestations are small blisters symmetrically distributed on the hands or feet, accompanied by obvious itching. It can be treated with topical glycerite lotion and oral antihistamines such as loratadine. Children with small blisters on their hands should go to the hospital in time, complete the relevant examinations to clarify the cause of the disease, under the guidance of the doctor symptomatic treatment, avoid unauthorized use of drugs.