Patients with advanced bone cancer may have the following signs before they die: firstly, they may have very severe and unrelieved pain around the body. Once reaching this stage, there will often be metastases around the body, resulting in severe pain around the body; second, there may be severe cachexia, when the patient often has severe weight loss and cannot eat, and there may be changes in skin color or shape, resulting in the patient’s appearance and physique becoming very poor; third, there may be a series of respiratory and circulatory failure, such as the patient Fourth, the patient may have a series of respiratory and circulatory failure, such as the patient’s breathing may become very weak, and the heartbeat may become too fast or very slow, until the gradual emergence of respiratory and cardiac arrest; fourth, the patient may have consciousness-related disorders, such as the patient may appear coma or delirium, and some patients may suddenly appear mentally awake before death, which is what the people call the return of light.