Soreness, swelling and pain in the legs during nighttime sleep. First of all, we need to clinically exclude whether there has been excessive exercise and muscle strain in the lower limbs recently. When there is excessive exercise will cause the muscle oxygen demand increases, which leads to lactic acid accumulation, thus triggering soreness, swelling and pain and other uncomfortable symptoms. There is another reason, female patients with age, endocrine hormone level regulation, resulting in low calcium, osteoporosis, can stimulate the leg soreness, discomfort and other symptoms. Not paying attention to the warmth of the legs at night, blood circulation disorders, resulting in peripheral sensory abnormalities, which is manifested as soreness, swelling and discomfort. It is necessary to address the specific causes in the clinic and then make a targeted treatment program.