Taking insulin has no significant effect on the kidneys. Insulin is the only hormone in the body that can lower blood glucose, and diabetics have absolute or relative insulin deficiency in their bodies, so they can be treated with exogenous insulin. A common adverse reaction to insulin shots is hypoglycemic reaction, which will be manifested by hunger, dizziness, weakness, fatigue, sweating, palpitations, irritability, or even fainting, convulsions, and coma. In addition, there will be allergic reactions, edema, weight gain, refractive errors, and redness, swelling and warmth of the skin at the injection site, and long-term injection in the same area may lead to lipoatrophy. However, there will be no significant effect on the kidneys. It is recommended that diabetic patients regulate the use of insulin under the guidance of a doctor.