Lung cancer without gene mutation indicates that the growth of tumor cells has not mutated. Lung cancer without gene mutation may belong to a single type of cancer, this situation will not increase the difficulty of tumor treatment, and most patients’ condition can be controlled after regular treatment, with good prognosis and improved survival rate. Lung adenocarcinoma gene test without mutation also indicates that patients can cooperate with doctors for targeted therapy at present. Because the development of tumor may be related to the gene mutation of a certain targeting point, the efficacy of targeted drug therapy is clearer when targeting a certain gene mutation. For known gene mutations that have been detected, genetic testing can be done before using drugs, and then targeted therapy can be carried out. Early diagnosis and treatment of lung cancer can improve the survival time of patients and prevent metastasis, so once diagnosed, systematic treatment should be carried out to avoid delaying the disease.