Sinusitis is mostly caused by gram-positive coccus or negative bacteria infection, you can choose broad-spectrum antibiotics such as penicillin, cephalosporins, macrolide antibiotics. Sinusitis is a general term for inflammatory diseases of the mucous membrane of the sinuses, divided into acute sinusitis and chronic sinusitis, the main manifestations of nasal congestion, runny nose, headache and so on, often accompanied by decreased sense of smell, usually non-infectious, no heredity. In the acute stage, if there is a high fever, a lot of pus and headache, you need to take antibiotics as prescribed by the doctor to treat it, and if there are clear gram-positive cocci or negative bacteria, you can choose broad-spectrum antibiotics such as penicillin, cephalosporins, macrolide antibiotics, such as amoxicillin, cefuroxime, azithromycin, clarithromycin, etc. If there is a combination of anaerobic infections, it is also necessary to use dinitroxil or metronidazole to treat it in a comprehensive way. Chronic sinusitis guidelines recommend small doses of 14 metacyclic macrolides for long-term oral administration for a period of not less than 12 weeks, such as azithromycin. Specific medication needs to consult the doctor, in the regular hospital for treatment, to avoid serious adverse reactions.