Taking Metformin generally does not increase weight, generally not fat. Due to the different physique of each person, there is variability in the adverse reactions after taking metformin, if there is any discomfort after taking metformin, consult a doctor promptly. The main pharmacological effect of metformin is to reduce blood glucose by inhibiting hepatic glucose output, improving the sensitivity of peripheral tissues to insulin, and increasing the uptake and utilization of glucose. Metformin may help to delay or ameliorate diabetic vascular complications by improving lipid profiles, increasing fibrinolytic system activity, decreasing platelet aggregation, and causing inhibition of smooth muscle cell and fibroblast growth in the arterial wall. Metformin decreases HbA1c by 1% to 2%. Common adverse effects of metformin are gastrointestinal adverse effects such as nausea and diarrhea. You need to follow your doctor’s instructions when taking metformin.