Generally speaking, there is no direct causal relationship between the onset of vitiligo and the type of work. However, according to statistics, hydrogen peroxide, liquid nitrogen, artificial fragrances, rubber manufacturing, benzene processing, etc. can cause skin depigmentation and secondary vitiligo to sensitive people. So people who are often exposed to the above substances should pay attention to the self-protection of the skin to prevent secondary vitiligo. Some chemicals have selective destructive effects on melanocytes, which can lead to skin depigmentation, such as antioxidant hydroquinone derivatives as raw materials for rubber protective gloves can cause permanent skin depigmentation of hands and upper limbs at the contact site; wearing sandals made of synthetic rubber can also produce the same lesion; operators who produce these products can also occur skin depigmentation. Experimental studies have also confirmed that p-tert-butylphenol, hydroquinone, hydroquinone monophenylether, betaine mercaptoethylamine hydrochloride, N-(2-mercaptoethyl)-dimethylamine hydrochloride and other chemicals can cause skin or hair decolorization in guinea pigs, mice, cats or rabbits. This is a problem in the production of p-tert-butylphenol or p-tert-butylphenol as raw material for the production of phenolic resins or adhesives for leather products in the automotive industry (production of car seat cushions, roof linings, car layer interiors), leather industry (manufacture and repair of leather boots); hospital cleaners who use disinfectants containing p-tert-butylphenol and o-phenol as house disinfectants, workers in the tanning industry and other industries who wear acid-resistant rubber gloves containing p-tert-butylphenol monophenyl ether; exposure to p-tert-butylphenol containing Tert-butyl catechol wear agents and dihydroxybiphenyl as an anti-aging agent for the production of latex products workers are also likely to occupational white spots.