Carcinoma thrombosis of the right branch of portal vein is usually treated by drug therapy, surgery and radiofrequency ablation. Right branch of portal vein thrombosis is a common complication of primary hepatocellular carcinoma and an important factor affecting the prognosis of hepatocellular carcinoma. Clinically, it can be categorized into proliferative, mixed and necrotic types. Drug treatment mainly involves the use of anticoagulants, commonly used as low molecular weight heparin or warfarin. But only taking some targeted drugs without surgery is not very effective and the drugs are very expensive. If the situation permits, surgery will be taken to improve the patient’s symptoms and quality of life. On the basis of intervention, medication or immunotherapy to control the primary tumor, radiofrequency ablation can be used to ablate the cancerous embolus of right branch of portal vein cancer embolus type I and type II, i.e., the cancerous embolus is confined to the liver, and it can achieve good results. The treatment of right branch of portal vein cancerous embolus should be diagnosed specifically, and according to the doctor’s advice, choose the suitable way of treatment, which can reduce the probability of recurrence, improve the quality of life and prolong the survival period effectively. The use of drugs needs to follow the doctor’s prescription.