Cough, sputum, and asthma symptoms often occur in the elderly, especially in long-term smokers, and are overwhelmingly due to chronic obstructive pulmonary disease (COPD). However, some patients with chronic cough and asthma symptoms, anti-infective and asthma treatment has little effect, it is necessary to rule out a special gastric disease – gastroesophageal reflux disease. Gastroesophageal reflux disease (GERD) is very common in Western countries, with about 7% to 15% of the population suffering from the disease, and the peak age group for the disease is 40 to 60 years old. GERD is a dysfunctional disease of the digestive tract, in which the reflux of gastric and duodenal contents into the esophagus causes heartburn, chest pain, acid reflux, and dysphagia. In a few patients, extra-esophageal symptoms such as asthma and coughing are the first or main manifestations of GERD, and in severe cases aspiration pneumonia, idiopathic interstitial fibrosis, and oral and pharyngeal symptoms may occur. Patients suspected of having GERD may undergo tests such as dye-guided frightening 24-hour esophageal PH monitoring and esophageal manometry to confirm the diagnosis. GERD patients should change their lifestyle and dietary habits, raise the head of the bed 15-20cm at night, avoid eating 2 hours before bedtime, and should not lie down immediately after eating during the day to reduce reflux. Pay attention to reduce all the factors that can lead to increased abdominal pressure, such as obesity, constipation, tight girdle and so on. Eat less high-fat food, chocolate, coffee, strong tea, quit smoking, alcohol. The treatment of gastroesophageal reflux disease is first recommended to promote gastrointestinal dynamics of drugs (such as mosapride, morcellators, etc.) and proton pump inhibitors (such as omeprazole, lansoprazole, etc.) combined application, for the disease caused by chronic cough, asthma can often be significantly improved. However, anti-reflux surgery can be considered for GERD that is ineffective with medication, or combined with lower esophageal sphincter defects, or combined with diaphragmatic hernia.