Olmesartan ester and candesartan ester are both metabolized by the liver and kidneys, but the degree of metabolism is different. 1. Olmesartan ester: Olmesartan ester is absorbed through the gastrointestinal tract after oral administration, rapidly and completely de-esterified and hydrolyzed to olmesartan, and the peak concentration of the blood drug is reached after 1~2 hours of oral administration, and eating does not affect the bioavailability of olmesartan. After olmesartan ester is rapidly and completely converted to olmesartan, there is no further metabolism of olmesartan, and about 35%~50% of the absorbed drug is excreted in the urine, while the rest is excreted in the feces through the bile. 2. Candesartan ester: Candesartan ester is the precursor drug of candesartan, during the absorption through the gastrointestinal tract, it is rapidly and completely hydrolyzed to candesartan, the absolute bioavailability of candesartan is about 15%, and the peak time of plasma candesartan concentration is 3-4 hours. The binding rate of candesartan to plasma proteins is more than 99%, and candesartan rarely passes the blood-brain barrier, but can cross the placental barrier. Candesartan is excreted primarily in its original form in the urine and feces, with a small portion reacting in the liver to form inactive metabolites. Olmesartan and Candesartan are commonly used drugs in the clinic, they have similar pharmacological effects, and should be used under the guidance of a professional if needed. Reference: “Instructions for Olmesartan Ester”, “Instructions for Candesartan Ester”.