Choledocholithiasis is a kind of stone on the liver and gallbladder, which has a high incidence and many causes. Choledocholithiasis is characterized by high incidence, inaccessibility of stone removal and difficulty in lithotripsy, etc. There is no special treatment at home and abroad, thus many patients with intrahepatic choledocholithiasis cause cholestasis, cirrhosis and even liver cancer due to lack of effective treatment. Clinically, patients often present with right upper abdominal cramps, chills and fever, jaundice and Charcot’s triad. In severe infections, shock and psychiatric abnormalities may occur (Reynokds’ pentad of symptoms), and biliary cirrhosis, followed by portal hypertension, may develop over time. According to the location of the stone, there are extrahepatic bile duct stones and intrahepatic bile duct stones. Treatment of extrahepatic bile duct stones 1.Laparoscopic choledochotomy with T-tube drainage is suitable for simple bile duct stones with open upper and lower bile ducts and no stricture or other lesions. If accompanied with gallbladder stones and cholecystitis, cholecystectomy can be performed at the same time. 2.Laparoscopy + choledochoscopy minimally invasive cholecystectomy (1) for single gallbladder stones; (2) multiple gallbladder stones; (3) gallbladder stones with or without symptoms; (4) gallbladder stones with recurrent biliary colic attacks; (5) no stone ton; (6) non-acute inflammatory disease; (7) good bile permeability; (8) gallbladder wall thickness 0.3~0.5cm; (9) gallbladder contraction function ≥30% after lipid meal ; (10) the patient voluntarily requested biliary preservation therapy (11) Treatment of intrahepatic bile duct stones “choledochoscopic holmium laser lithotripsy” is a treatment using holmium laser without open bleeding, but through a soft optical fiber, after entering the cavity through the choledochoscope-like endoscopic working channel, against the stone, the powerful energy of holmium laser pulse point shot to the stone to be crushed, the generated The energy generated can vaporize the water between the end of the fiber and the stone, forming tiny vacuoles and transmitting the energy to the stone, causing the stone to be crushed into powder form, the whole process is carried out under precise computer monitoring, so it is not easy to accidentally injure the surrounding normal tissue.