Pain on pressure at the bone next to the eye of the medial knee is considered to be related to injury of the medial collateral ligament, injury of the medial meniscus, osteoarthritis and other reasons. 1. Medial collateral ligament injury: the medial collateral ligament is located in the medial side of the knee joint, when there is a sprain or other injuries to the knee joint, it may cause injury to the medial collateral ligament, which may result in pain when pressing on the bone next to the eye of the medial knee. 2. Meniscus injury: the medial meniscus is located in the medial side of the knee joint, which can play a certain role in relieving the stress of the joint and lubricating the joint. When the medial meniscus is damaged, there will be pain when pressing on the bone next to the eye of the medial knee. 3. Osteoarthritis: caused by degenerative joint disease, patients will have degenerative damage to the articular cartilage, with the progress of the disease will appear subchondral bone damage, when pressing the medial knee eye next to the bone, there will also be pressure pain. There are many reasons for the pressure pain at the bone next to the medial knee eye, if the pain is severe or frequent, you should go to the hospital in time to further find out the cause of the disease, and then targeted treatment.