Early stage of duodenal cancer usually has no obvious symptoms, and some patients will have abdominal pain, nausea and other symptoms. With the development of the disease, patients may have symptoms such as blood in stool, vomiting and so on. Early stage of duodenal cancer usually has no characteristic clinical symptoms, and some patients may have slight manifestations, such as abdominal pain, nausea, jaundice and so on. If the patient’s condition develops further, there are symptoms such as blood in stool, vomiting, bleeding, anemia, etc. Some patients may also have symptoms such as loss of appetite, diarrhea, abdominal mass, weight loss and general weakness. Patients with duodenal cancer can generally take surgical treatment, and pancreaticoduodenectomy is the first choice. In addition, duodenectomy, partial papillotomy and major gastrectomy can also be chosen. To sum up, the early symptoms of duodenal cancer are not characteristic. If the patients experience abdominal pain, nausea, jaundice and other discomforts, they should seek medical treatment in time to find out the cause of the disease and take regular treatment under the guidance of doctors.