Small molecule peptide belongs to protein fragment, which has extremely strong activity and diversity, and is applied in cosmetics, food industry, medicine and other aspects. But the clinical use of small molecule peptide has certain contraindications, so the following groups should be avoided in the doctor’s advice: 1, patients with poor digestive function: small molecule peptide is protein, and protein is more difficult to be digested and absorbed. The intake of small molecule peptide by patients with poor digestive function may bring burden to the digestive function; 2.Patients with high blood sugar: Patients with high blood sugar should not use small molecule peptide, because small molecule peptide will lead to the elevation of liver glycogen and muscle glycogen in patients’ body, and then increase blood sugar; 3.Patients with low cholesterol: Small molecule peptide can also promote cholesterol excretion, so as to effectively reduce the concentration of cholesterol, so patients with low cholesterol should not The consumption may make the condition more serious.