Normal people generally speaking do not have a large amount of protein in the urine, because protein belongs to large molecules, and can not be eliminated by the kidneys in large quantities. However, there are some physiological or pathological conditions that can lead to increased urinary protein. The most common physiological conditions are under stress, such as high fever, strenuous exercise, surgery and trauma, or due to pregnancy and other factors can cause a transient increase in urine protein. But this situation in the triggering factors removed, the patient will return to normal. However, if the patient does not have some stress factors under the condition of increased urinary protein, we should check whether there are renal diseases or extra-renal diseases caused. Clinically, the most common cause of increased urine protein is primary kidney disease, such as glomerulonephritis. In addition, other diseases such as allergic purpura, or epidemic hemorrhagic fever involving the kidneys, rheumatic immune system diseases, drug poisoning, etc. may cause increased urine protein. Therefore, it is important to complete the relevant examinations under the guidance of the doctor, and early intervention and treatment, so as not to cause further damage to the kidneys.