Lying down at night and not being able to breathe may be caused by some diseases, such as bronchial asthma, cardiac insufficiency, sleep apnea hypoventilation syndrome and so on. 1. Bronchial asthma: manifested by repeated episodes of wheezing, chest tightness or coughing and other symptoms, often at night or aggravated. It is recommended to consult a doctor in time to clarify the diagnosis. Generally, anti-inflammatory drugs (such as budesonide formoterol inhalation powder aerosol) and antispasmodic asthma drugs (such as salbutamol) can be relieved after treatment. 2. Cardiac insufficiency: Cardiac insufficiency can lead to bruising of the lungs, which can cause varying degrees of dyspnea. Dyspnea is often aggravated when lying down at night. The mechanism includes the redistribution of blood to increase pulmonary blood volume when lying down, increased vagal tone at night, constriction of small airways, elevation of the diaphragm, and decreased lung capacity. The treatment is mainly to improve cardiac function and control the in and out volume. 3. Sleep apnea and hypoventilation syndrome: mainly manifested as night snoring, apnea, waking up during sleep, daytime drowsiness, fatigue, etc., which need to be diagnosed with the help of polysomnography. Treatment includes weight reduction, change of sleep position and correction of underlying diseases, etc. Ventilator can be worn during night sleep. In addition to the above diseases, airway occupying diseases, respiratory tract infections, mental illnesses, etc. can also occur at night when lying down breathlessness, should promptly consult a doctor for examination, according to the cause of the disease to take appropriate treatment, the above drugs should be used under the guidance of a physician.