Patients are not recommended to drink alcohol when taking antihypertensive drugs because the ethanol in alcohol will be released and decomposed into acetaldehyde after drinking large amounts of alcohol, which will leave the surrounding capillaries in a permeable open state of microcirculation, causing secondary failure of antihypertensive drugs, and will cause the blood pressure to first fall and then rise. It can cause further opening of arteriovenous short circuits and direct pathways, resulting in the opening of capillary permeability in the patient and causing a transient and fluctuating drop in blood pressure. As the alcohol is metabolized, the patient’s blood pressure will experience a further increase. In addition, for patients with a history of hypertension, if they have consumed a large amount of alcohol, the sympathetic nerves will be overexcited and cause a further increase in blood pressure, resulting in increased blood pressure, increased heart rate, and increased myocardial oxygen consumption, leading to unstable blood pressure and angina pectoris.