Severe pustular acne is the severe stage of acne, with serious infections and lesions manifesting as pustules, which can be treated with topical medications, oral medications or physical means. 1. Topical drugs: patients can use erythromycin ointment, fusidic acid cream, azelaic acid gel or adapalene gel and other topical drugs to improve the relief, but need to pay attention to the application of drugs should be based on the guidance of the doctor, and combined with the selection of personal circumstances. 2. Oral medication: severe pustular acne patients, but also by taking isotretinoin soft capsules, spironolactone tablets or prednisone acetate tablets, clindamycin and other drugs for treatment. 3. Physical means: if through drug treatment, can not achieve better therapeutic effect, if necessary, but also through photodynamic therapy, laser therapy and other physical means to carry out treatment. If the symptoms of acne is more serious, you need to go to the hospital in time to check the symptoms, and according to the development of the disease and the individual situation to take targeted treatment measures, to avoid misunderstanding the condition leading to further aggravation of the symptoms, resulting in serious adverse effects, usually should pay attention to light diet, avoid staying up all night.