Large fluctuations in blood pressure are relatively more destructive, increasing the impact on the blood vessels, which may cause them to rupture and cause hemorrhage. Blood pressure fluctuations are mainly due to arterial sclerosis, making hemodynamic changes, due to the patient’s blood pressure fluctuation is too large, the blood vessels will be subjected to large fluctuations in blood pressure impact, so not only will lead to patients with increased risk of vascular rupture, but also increase the incidence of stroke and other cardiovascular and cerebral vascular diseases rise. For patients with large fluctuations in blood pressure, they should be treated with lipid-regulating drugs and antihypertensive drugs under the guidance of a doctor, commonly used drugs include atorvastatin calcium, metoprolol, and nifedipine, etc., and risk factors such as emotional excitement and strenuous exercise should be avoided. Therefore, for patients with large fluctuations in blood pressure, it is best to go to the hospital for 24-hour blood pressure monitoring, checking the function of important organs, and after discovering the cause of the disease, timely targeted treatment.