Hand sweating can be treated by injection of botulinum toxin, because botulinum toxin can inhibit the release of acetylcholine. Its contraindications include allergy, infection, etc., and its adverse reactions include injection reaction and atopic reaction. The mechanism of action of botulinum toxin for the treatment of hand sweating is as follows: the exocrine sweat glands and parietal sweat glands are all mediated by acetylcholine, and the currently used botulinum toxin type A can inhibit the release of acetylcholine from the nerve axons at the neuromuscular junction, thus achieving the effect of chemical denervation. Therefore, hand sweating can be treated by injecting botulinum toxin. However, there are the following contraindications to Botox treatment of hand sweating: allergy to botulinum toxin type A or its components; localized infections; patients with myasthenia gravis; pregnant and breastfeeding women; with major systemic diseases or acute infectious diseases. Avoid the use of drugs such as aminoglycosides for 2 weeks before and after treatment to avoid affecting neuromuscular transmission. The treatment may also appear in the local swelling and pain erythema, nausea and headache, muscle weakness and other adverse reactions, so patients who wish to be treated are recommended to go to a regular medical institution, under the guidance of specialists to standardize the treatment, so as not to cause adverse consequences.