Antihypertensive drugs can be taken orally after meals, but in most cases, antihypertensive drugs are usually taken orally in the morning, because the commonly used antihypertensive drugs in clinical practice are long-acting extended-release preparations, which are usually taken once a day, so patients are instructed to take them orally in the morning when they wake up every morning. Because blood pressure has a characteristic, the morning blood pressure will be higher than the daytime, but some patients because of individual differences, blood pressure fluctuations are not the same, for example, some patients in the afternoon or in the evening blood pressure is high, so in the oral antihypertensive drugs according to the individual situation. Half an hour to an hour before the observation of high blood pressure to take antihypertensive drugs, can be effective in lowering blood pressure, at the same time oral antihypertensive drugs should be monitored after blood pressure. In conclusion, blood pressure shows a “spoon” curve, generally speaking, the highest in the morning, the patient needs to take medication early in the morning; however, some patients with hypertension show a “anti-spoon” curve, the performance of evening or even nighttime blood pressure is high, such patients need to take medication in the middle of the day or at night.