Madrone’s disease is also known as benign symmetric lipomatosis. Patients mainly have painless fatty masses, neck deformity, limited neck movement, and some patients may have dyspnea and dysphagia. Benign symmetric lipomatosis is most common in middle-aged men, the patient’s fat will be diffusely deposited in the upper part of the body, especially in the neck, there will be painless fat lumps, the appearance of the “cow’s neck” or “hump back”, usually lead to neck deformity, limited movement. It usually leads to neck deformity and limited mobility. Some patients may also experience dyspnea, breathlessness, dysphagia, etc., due to the pressure of the fat mass, and may cause venous return obstruction when it presses on the vena cava. Benign symmetric lipomatosis is often combined with some medical diseases, such as chronic alcoholic liver disease, diabetes mellitus, hyperuricemia, anemia, hypothyroidism, and so on. When these symptoms occur, the patient should seek medical treatment in time to avoid serious impact on life.