Pancreatic bulge may be caused by pancreatic inflammation, pancreatic polyp, pancreatic cancer, etc. It can be treated by taking acid inhibitors such as omeprazole, gastric mucous membrane protectants such as magnesium aluminum carbonate, and antibiotics such as amoxicillin. 1. Acid inhibitors: they can inhibit the secretion of gastric acid and reduce the stimulation of gastric acid to cardia, and are often used as proton pump inhibitors such as omeprazole or rabeprazole. Headache, diarrhea, allergy and other adverse reactions should be noted. 2. Gastric mucosal protective agent: such as magnesium aluminum carbonate, aluminum magnesium plus suspension, aluminum thioglycollate and other gastric mucosal protective agents, can reduce the stimulation of the lesion site. When taken orally, attention should be paid to the occurrence of dyspepsia, diarrhea, vomiting and other adverse reactions. 3. Antibiotics: anti-infective treatment with drugs such as amoxicillin or levofloxacin can help relieve cardia bulge. Be aware of the occurrence of adverse reactions such as allergy, nausea and vomiting. The above drugs should be used under the guidance of a medical professional. The appearance of cardia bulge should promptly seek medical treatment under the guidance of a professional physician to avoid delaying the condition.