Reflux esophagitis is generally a benign condition and rarely becomes cancerous. The exact time of cancerous transformation depends on the severity of esophagitis and the patient’s personal condition, and there is no exact time, usually ranging from a few years to a few decades, or it may not be cancerous for a lifetime. If the condition is mild, the damage to the esophageal mucosa is small, and the patient receives active and effective treatment, cancer will not occur in general. If the disease is serious and the esophageal mucosa is irritated by inflammation for a long period of time, it may lead to cancer as the disease progresses. It may take 10 years or even decades for cancer to develop if the disease is treated actively, but it may develop in 2-3 years if the disease is not treated effectively. Patients with reflux esophagitis should pay attention to their life, usually reduce the intake of stimulating food, do not eat too hard and too hot food, and learn the good habit of chewing and swallowing slowly. If reflux esophagitis exists, it is recommended to go to the hospital as soon as possible to get regular and effective treatment under the doctor’s guidance, so as to reduce the possibility of cancer.