In modern society, the quality of life has gone up, but the quality of the population has gone down, and it is increasingly difficult to have a healthy and smart baby. There are countless reasons for infertility, and this time, another one is uncovered, what is it called – immune infertility. It is a good idea to look at what is happening to your male friends. What are the dangers of immune infertility? (1) affect embryonic development, there are many causes of immune infertility, such as infection, bilateral genital tract obstruction, external testicular injury (sprain), testicular biopsy, cryptorchidism, varicocele, homosexuality (anal sex), etc., especially to ask whether there is a history of vasectomy. Any cause of sperm antibody formation due to destruction of blood-testis barrier in testis, infection of accessory gonads, testis affected by high temperature or injury, etc. can cause immune infertility. (2) Closure of the zona pellucida recognition site on the acrosome membrane and inhibition of sperm attachment to and penetration of the zona pellucida. (3) Affecting the activity of sperm enzymes and inhibiting the dispersal of zona pellucida and radial crown, including acrosome protease: which promotes sperm penetration through zona pellucida and facilitates sperm-egg fusion; and sperm hyaluronidase: which disperses the egg mound (radial crown). Sperm antibodies mainly interfere with sperm dispersal by inhibiting the activity of hyaluronidase. (4) Preventing sperm from crossing the cervical mucus, anti-sperm antibodies can cause sperm to agglomerate into clumps and impede sperm activity. Sperm braking antibodies have cytotoxic reactions that cause sperm death or interfere with sperm motility. In addition, there may be some effects on sperm metabolism and sperm contractile protein function. Treatment of immune infertility: (1) Immunosuppressive therapy: glucocorticoids are used. Some patients may have the possibility of conception after receiving 1 to 3 courses according to the menstrual cycle of the spouse. (2) Testicular rebound therapy: A few men with autoimmune infertility do not have a reduced number of sperm, some even have many, and therefore the number of anti-sperm antibodies increases abruptly. (3) Sperm washing: sperm washing and intrauterine insemination of the female partner. (4) Etiological treatment: Inflammation of the male reproductive tract should be treated actively, and the earlier and more timely the anti-infection treatment, the better the general treatment period is 6 to 12 months. For those who have infertility due to testicular tissue damage and epididymal lesions producing self anti-sperm antibodies, surgical treatment should be performed to eliminate the foci of immune reaction and possibly improve fertility.