Hepatitis B surface antigen 40IU/ml has little chance of turning negative naturally, and Hepatitis B surface antigen 40IU/ml should be turned negative through treatment. Hepatitis B surface antigen 40IU/ml suggests that the body carries the hepatitis B virus and may be suffering from acute hepatitis B or chronic hepatitis B, etc. Most of the patients are difficult to turn negative by natural means and need active treatment to turn negative. Hepatitis B surface antigen 40IU/ml needs to be treated to achieve the effect of conversion, if it is acute hepatitis B patients, you can choose entecavir or tenofovir and other drugs to fight the virus, eat more protein, vitamins and other nutritious food; if it is chronic hepatitis B patients, you can use interferon and other drugs, together with the compound glycyrrhizin tablets and other drugs to nourish the liver. The use of medication should be directed by a doctor. Patients with hepatitis B surface antigen 40IU/ml need to go to the regular hospital in time, and be guided by the doctor to help turn negative.