Once they hear that it is pancreatic cancer, patients and their family members will be confused and panic-stricken, and they will consult everywhere with their medical records. Before listening to multiple opinions, they should do the following homework: know which hospital and which specialist is specializing in pancreatic cancer; prepare medical records, laboratory results and ultrasound, CT, MRI and other imaging results; and think about what questions to consult the specialists beforehand. In order to avoid long distance travel and still end up in the clouds and confused. Case: Male, 69 years old. Deep yellow urine, itchy skin for one month, weakness appeared half a month ago, weight loss from 53 kg to 47 kg, outpatient at the local hospital on August 8, the whites of the eyes turned yellow, liver function was checked, several indicators were super high, combined with ultrasound showed the diagnosis of obstructive jaundice, further examination, MRI showed that the gallbladder, intrahepatic bile duct and common bile duct were significantly dilated, the head of the pancreas area was rattle-like, judged to be a tumor of the head of the pancreas compressing the common bile duct, resulting in obstructive jaundice. Question 1: How to determine whether it is a malignant tumor? Before surgery, physicians mainly determine the possibility of malignant tumor based on the patient’s clinical manifestations, laboratory results, tumor indicators and imaging examinations, and the final diagnosis depends on pathological section examination. Generally speaking, physicians mainly decide whether to operate based on clinical manifestations and examination results, rather than waiting for the pathological section to confirm the diagnosis of malignant tumor before operating. Question 2: Can pancreaticoduodenectomy be performed? A resectable pancreatic tumor must have the following points: 1) no extra-pancreatic lesions; 2) no direct invasion of the celiac artery and superior mesenteric artery by the tumor; 3) no obstructive invasion of the superior mesenteric-portal vein by the tumor. Therefore, before open surgery, physicians mainly judge resectability based on CT and MRI. Question 3: Is pancreaticoduodenectomy surgery risky? As long as there is no significant damage to the major organ functions, theoretically, pancreaticoduodenectomy should be tolerated, not to mention that the level of surgical techniques, anesthesia management and postoperative monitoring is now much higher than before. Question 4: What should be done if surgery is not possible? Palliative treatment and symptomatic treatment for unresectable pancreatic cancer should be the main focus to relieve patients’ pain and prolong their lives as much as possible. If the tumor is judged to be unresectable intraoperatively, the physician will recommend biliary-intestinal anastomosis and gastrointestinal anastomosis to resolve biliary obstruction and prevent duodenal obstruction. If the physician determines from the beginning that surgery is not possible, minimally invasive internal or external bile drainage will be arranged to resolve jaundice caused by bile duct obstruction, or to place a duodenal stent to resolve vomiting caused by intestinal obstruction. The need for chemotherapy will vary from person to person and will be judged by the medical oncologist. Advanced pancreatic cancer may face pain problems and should be given reasonable and effective pain relief treatment. Question 5: What is the effect of pancreatic cancer treatment? Pancreatic cancer is known as the stubborn bastion of medicine in the 21st century because of its late detection, rapid development and poor prognosis. 80% of patients have already infiltrated the surrounding large blood vessels and important organs and cannot be removed at the time of consultation, so the average survival time is less than 6 months. Only about 20% of patients can be treated surgically, and the 5-year survival rate after surgery is less than 5%. Compared with progressive pancreatic cancer, the surgical resection rate of early stage pancreatic cancer is 90%~100%, and the 5-year survival rate can reach 70%~100%, and there is a great contrast in its treatment effect. Therefore, early diagnosis of pancreatic cancer should be emphasized.