Alcohol should be consumed one week after a penicillin shot. This is related to the drug metabolism time and metabolic pathway of penicillin. Penicillin drug metabolism half-life is 24~48 hours, a week after the penicillin can be completely metabolized out of the body, then drinking alcohol will not have an adverse reaction with penicillin, and will not affect the efficacy of penicillin. If you drink alcohol within a week, it may cause disulfiram reaction, drowsiness, headache and other symptoms, and in serious cases, it can be life-threatening. Therefore, it is recommended to drink alcohol after one week of penicillin. Pay attention to the skin test before infusion of penicillin, some people are allergic to penicillin, if directly injected, it may cause drug anaphylactic shock, requiring timely rescue.