The apical grade 2/6 systolic murmur is a functional murmur, which can be seen in exercise, fever, anemia, hyperthyroidism, as well as hypertension, dilated cardiomyopathy and so on. 1. Exercise: Exercise excites the sympathetic nerves, which strengthens the heart contraction, accelerates the heart rate, and speeds up the blood flow, which impacts the ventricular wall during systole and produces a functional murmur. 2. Fever: Fever puts the body at a high metabolic level, i.e., the basal metabolic rate rises, the heart rate increases, the blood flow rate becomes faster, and a functional murmur is produced. 3. Ejection of blood: the body is in a state of relative oxygen deprivation, the body by accelerating cardiac contraction and heart rate, so that the blood output increases, the blood flow rate becomes faster, producing a functional murmur. 4. Hyperthyroidism: the body is at a high metabolic level, the heart rate is accelerated, the blood flow rate becomes faster, producing a functional murmur. 5. Hypertension: the heart is overloaded, and when the left ventricle is dilated off-center, i.e., the ventricular cavity is enlarged, it causes relative closure insufficiency of the mitral valve, which produces a systolic murmur. 6. Dilated cardiomyopathy: especially the left ventricle dilation is obvious, resulting in the relative closure of the mitral valve insufficiency, thus producing a systolic murmur. Other diseases can also cause an apical grade 2/6 systolic murmur, such as coronary artery disease. If such a murmur is detected in the apical region of the heart, it is advisable to visit a cardiologist and seek medical advice.