Barrett translates to Barrett in Chinese. Barrett’s esophagus, also known as Barrett’s esophagus, is a complication of reflux esophagitis, and some patients are at risk of deteriorating into esophageal adenocarcinoma. Barrett’s esophagus is a pathological manifestation in which the complex squamous epithelium of the mucosa of the lower esophagus is replaced by a single layer of columnar epithelium similar to the inner surface of the gastrointestinal tract, etc. The specific pathogenesis of Barrett’s esophagus is not clear. To some extent, gastroesophageal reflux disease increases the chances of developing the disease. Patients with Barrett’s esophagus mainly present with GERD symptoms such as acid reflux, heartburn, difficulty in swallowing, and retrosternal pain. For treatment, acid suppressants, such as Rebeprazole tablets, Domperidone tablets and other medications can be taken appropriately under the guidance of the doctor, and surgery can be performed if necessary. If the patient has long-term heartburn, acid reflux, heartburn and other symptoms, it is recommended to go to the gastroenterology department of regular hospitals in a timely manner, and if necessary, do endoscopy and esophageal mucosal histopathology to exclude Barrett’s esophagus disease.