Cranial defects are a relatively common craniocerebral disorder, especially in modern society, where traffic safety accidents and production safety accidents are frequent, which are likely to cause damage to the skull, as well as cranio-cerebral surgery, which may also damage the skull in many cases. Therefore, the incidence of skull defects is relatively high. When a skull defect occurs, timely repair of the skull becomes an urgent issue. If it is not repaired in time, it will cause a lot of damage to the organism and many adverse effects. In a large range of cranial defects, the patient’s localized scalp subsidence due to atmospheric pressure may lead to an imbalance of intracranial pressure, displacement of brain tissues, as well as a decrease in hemispheric blood flow and cerebrospinal fluid circulation disorders, which will lead to a series of clinical manifestations, including: headache, vertigo, irritability, epilepsy, no other reason can explain the discomfort and various mental disorders. Titanium mesh is the most widely used cranial bone repair material in China now currently in clinical practice, titanium is the material with higher hardness and lighter quality among metals. Titanium mesh is suitable for cranial bone repair material, and titanium mesh can be better restored to the shape of the skull through computerized shaping. However, titanium mesh also has some disadvantages, because titanium mesh is a relatively thin layer of metal mesh plate, the thickness of only about 1mm, so the hardness of titanium mesh is not enough, especially for large areas of cranial titanium mesh, and again subjected to external forces are prone to deformation, resulting in titanium mesh indentation, and in serious cases, need to take out the titanium mesh, again surgery. Clinically, we have also seen such patients, who have already had a skull repair, but after the trauma, the titanium mesh is sunken in, even with bleeding, and need to be operated again. Therefore, it is necessary to pay attention to the protection of the surgical site to avoid re-injury after cranial titanium mesh repair. In fact, at present, there is a very excellent polyether ether ketone PEEK material. Although the cost of titanium mesh is slightly higher than that of titanium mesh, it is not very expensive, and it can effectively solve the various problems mentioned above. PEEK material is comparable to human skull in terms of elasticity, hardness, thermal insulation, stability, etc., and it can be customized in three dimensions, accurately anastomosed to the defective area, and it can be highly integrated with the autologous skull, so the repair effect is very good.