Cranial defect is a relatively common craniocerebral disorder, many reasons can cause cranial defect, such as traffic accidents, production safety accidents, falling objects, fighting, craniocerebral surgery, etc., can cause cranial defect. Cranial defects may cause a series of uncomfortable symptoms, and very unsafe, external impact bump may directly hurt the brain, and skull defects after the skull is very unattractive, resulting in psychological discomfort and even psychological disorders. Therefore, after the occurrence of cranial defects, it is necessary to carry out cranial repair in a timely manner. However, many patients may realize that there is a risk of infection after cranial repair, and are deterred from doing so. In fact, there is no need to worry too much about this, not only cranial bone repair, but also many surgical procedures have the risk of infection, but you should not choke on it. What everyone needs to do is to minimize the risk of infection, and this is something that doctors and patients need to work together to do. The first is surgical technique and perioperative care, and the second is the choice of materials for cranial bone repair. Titanium mesh, which is widely used in clinical practice, may pose a relatively high risk of postoperative infection, while a more advanced polyether ether ketone (PEEK) material has better performance and is less likely to cause postoperative infection. Surgical infection rates are also closely related to the skill of the surgeon and the overall perioperative management of the team. We have widely used the excellent performance of polyetheretherketone PEEK material to carry out PEEK cranial repair plastic surgery, and have achieved good results in the clinic. With advanced technology and perfect team management, not only can we achieve good results of cranial repair, but also well avoid cranial repair infections, and we have obtained good feedback from our patients.