The treatment of creatinine 300μmol/L should be decided according to the general condition of the patient, such as the patient has obvious nausea, vomiting, heart failure, edema, inability to lie down and obvious electrolyte metabolism disorders, hyperkalemia, acidosis, etc., which need to be actively carried out renal replacement therapy, hemodialysis or hemodiafiltration treatment. If the patient does not have any clinical manifestations of chronic renal failure caused by creatinine 300μmol/L, it is recommended that active renal therapy, the most commonly used renal drugs include oral renal drugs, oral Chinese medicine and Chinese medicine anal plugs, etc. The most commonly used renal drugs are Brylcreem, Brylcreem, Brylcreem and Brylcreem. The most commonly used drugs for kidney preservation are oral drugs, oral Chinese medicine and Chinese medicine anus. Oral drugs for kidney preservation include Bailing capsule, Renfukang, Jinshuibao, uremic acid granule, compound alpha keto acid, ferrous succinate, erythropoietin, sodium bicarbonate, medicinal charcoal, and so on.