Anlotinib is an anti-angiogenesis-based multi-target tyrosine kinase inhibitor, and in general the side effects are not particularly significant, but some people have serious side effects. The common side effects include hypertension, which has a high incidence, but this hypertension can be controlled by antihypertensive drugs, and fatigue. In addition is the skin reaction, especially the skin reaction of the hands and feet, easy to appear hands and feet skin peeling, this is also the middle of this class of drugs almost all exist side effects, you can use some urea ointment and other topical to improve the symptoms. There are also proteinuria, effects on blood lipids, mouth ulcers and diarrhea, loss of appetite, etc. There is also a relatively uncommon side effect of Anrotinib, namely hoarseness. Patients may be more nervous when they encounter this condition, but these can be managed by ultrasound nebulization, including hormones. In addition, side effects such as impairment of liver and kidney function, muscle pain, metritis, and tachycardia can also be reported, but the overall incidence is relatively low.