Vaginal soreness during urination and feeling of not being able to urinate, the possible clinical causes are urinary tract infection, urinary stones, urethral polyps and so on. 1. Urethral infection: the situation refers to the pathogenic microorganisms caused by the urinary tract infectious diseases, clinical manifestations of frequent urination, urinary urgency, painful urination, etc., the stimulation produced by the inflammatory reaction may cause stimulation of the muscles around the side of the vagina and related soreness symptoms. 2. Urethral calculi: This condition is mostly seen in people with metabolic abnormalities and urinary tract obstruction, which can occur in any part of the kidney, ureter, and urethra. When urethral stones appear, the clinical manifestations of urinary difficulty, urinary frequency, urinary urgency, urinary pain, etc., it will also cause irritation to the side of the vagina and soreness. 3. Urethral polyps: this is a relatively common female urethral disease, which is associated with repeated urinary tract infections, inflammatory stimuli will cause urethral mucosal hyperplasia secondary to the formation of urethral polyps, the clinical manifestations of urinary frequency, urinary urgency, urinary pain, and so on. It is recommended that people with related conditions should go to the urology department of the hospital for examination to make a clear diagnosis, so as to carry out targeted treatment.