Pancreatic cancer is known as the “king of cancers” because of its high mortality rate. The founder of Apple, Steve Jobs, Italian tenor singer Pavarotti and Hong Kong artist Shen Tianxia all died of pancreatic cancer. The cause of pancreatic cancer is still unknown, and once diagnosed, it is usually at an advanced stage with poor treatment and low survival rate. Therefore, the early detection of pancreatic cancer is of great importance. Type 3 diabetic patients develop pancreatic cancer within 1-2 years According to statistics, there are 100 million diabetic patients in China. Diabetes is caused by the problem of insulin secretion in the endocrine cells of the pancreas, while pancreatic cancer mostly comes from malignant changes in the exocrine structures of the pancreas. Among diabetic patients, some of them are closely related to pancreatic cancer. These patients are over 40 years old, have no family history of diabetes, are not obese, but suddenly develop unexplained wasting, and after treatment for diabetes with no obvious effect or very repeated treatment, pancreatic imaging and tumor markers are performed to exclude the possibility of pancreatic cancer. It is understood that such patients are known as type 3 diabetics and usually develop pancreatic cancer within 1-2 years. The cause of pancreatic cancer is still unknown, but it is related to factors such as diet, tobacco and alcohol, chemicals and chronic pancreatitis, especially poor diet and lifestyle habits. The incidence rate has increased from 4-5/100,000 in the past to 11-12/100,000 in major cities such as North, Shanghai and Guangzhou, which is on par with the developed western countries, and there is an increasing trend of youthfulness. Type 3 diabetic patients develop pancreatic cancer within 1-2 years Prof. Rufus Chen introduced that because the pancreas is located in the upper middle abdomen of human body, its anatomical location is special, adjacent to liver, gallbladder, stomach, duodenum and other organs, early clinical symptoms are easily ignored or confused with gastric disease, so it is easy to miss or misdiagnose, and most people are already in advanced stage once diagnosed. “At present, the treatment effect of early stage pancreatic cancer is more ideal. For pancreatic cancer that grows on the surface of the pancreas, less than 2 cm and has not metastasized, the five-year survival rate can reach 80% after surgical removal. In contrast, the five-year survival rate after surgery for mid-stage pancreatic cancer plummets to less than 20 percent, while advanced pancreatic cancer can only be treated conservatively to improve the patient’s quality of life, and the average survival time of patients is only a few months.” Pancreatic cancer is not easily detected in early stages Late stage survival rate is only a few months Since diabetes and pancreatic cancer are closely related, finding out who will get pancreatic cancer among diabetic patients is one of the most important ways to save pancreatic cancer patients. Professor Rufus Chen and his team have conducted a systematic study on this issue. For the first time in the world, they found that pancreatic cancer can cause diabetes through a substance called inflammatory factor, and further identified that MIF, which is an inflammatory factor, can cause dysfunction of pancreatic islet cells. Islet cells are the cells that produce insulin, and when their function is faulty, diabetes may follow. Further, we explored the mechanisms by which pancreatic cancer causes new-onset diabetes and found that systemic inflammation is an important mediator of both. The ability of anti-inflammatory drugs to alleviate abnormal glucose tolerance in animal models of pancreatic cancer-associated diabetes provides a theoretical basis for the treatment of pancreatic cancer. If pancreatic cancer is detected early, it will greatly improve the treatment outcome and prolong the survival time of patients.