High mean platelet volume may be triggered by pregnancy factors, excessive destruction of peripheral platelets, giant platelet syndrome and other disease factors. 1. pregnancy factors: women in the late stages of pregnancy, by the body of hormonal changes and other physiological factors, can also cause the body of blood platelet volume is high, usually after delivery can be restored. 2. Excessive destruction of peripheral platelets: the number of platelets in the body decreases, and the platelets in the bone marrow are not fully mature, resulting in the release of some larger platelets, which can also cause high average platelet volume. 3. Giant platelet syndrome: congenital giant platelet syndrome can also cause high platelet volume in the body. 4. Other disease factors: for example, the presence of malignant tumors can lead to the release of larger platelets in the bone marrow by the body; thrombosis and other diseases, can lead to high average platelet volume. High average platelet volume may also be due to other reasons, please go to regular hospitals in time to receive examination and treatment.