Pepsin may be high because the patient has duodenal ulcer, Helicobacter pylori infection or chronic gastritis, etc. Pepsin is elevated, mainly when gastric acid secretion is excessive. 1. Duodenal ulcer: patients with duodenal ulcer are prone to hunger pain in the upper abdomen, and increased secretion of gastric acid during hunger will lead to high pepsin. 2. Helicobacter pylori infection: patients with Helicobacter pylori infection, because the acidic environment is suitable for the survival and reproduction of Helicobacter pylori, Helicobacter pylori reproduction in the stomach, requires a large amount of gastric acid, which will lead to a rise in pepsin, so pepsin elevation and the Helicobacter pylori infection is positively proportional to the increase in pepsin. 3. Chronic gastritis: If the patient’s daily diet is not regular, and there are also smoking, drinking and other bad habits, long-term stimulation of the gastric mucosa, resulting in excessive secretion of gastric acid, then check the patient’s pepsin will be high. High pepsin may also be caused by other reasons, it is recommended that patients go to the hospital as soon as possible, identify the cause of the disease, under the guidance of the doctor for treatment.