Whether the mouth is crooked for many years can be cured, it should be determined what causes the crooked mouth, more common three diseases: 1, central facial palsy, generally caused by cerebrovascular disease is more common, also seen in brain trauma or brain tumor, etc.. In this case, it can no longer be cured in more than half a year and is a sequela. 2. peripheral facial palsy, usually caused by idiopathic facial neuritis, may also be trauma or tumor compression, this condition generally can no longer return to normal in more than 2-3 months, so crooked for many years can not be cured. 3. facial muscle spasm, a disease caused by hyperfunction of the facial muscle, will make the mouth crooked to the focal side. If the symptomatic treatment with drugs can reduce the symptoms, you can also consider botulinum toxin injection to make facial muscle spasm relief, and may be cured.