Herpes simplex virus type 2 positivity may affect the fetus; the herpes simplex virus can infect the fetus through the placenta. Herpes simplex virus type 2 is mainly sexually transmitted, which leads to genital herpes. If a woman in pregnancy tests positive for herpes simplex virus type 2, the herpes simplex virus virus may infect the fetus through the placenta, perhaps resulting in adverse outcomes such as miscarriage, stillbirth, and congenital malformations. If a pregnant woman is diagnosed with genital herpes, it may be transmitted to the newborn through the birth canal during labor and delivery, and neonatal herpes, or in severe cases, systemic symptoms or encephalitis, may occur. If the test result is positive for herpes simplex virus type 2, all of them have a certain chance to affect the fetus and cause neonatal infection.