Children with bedwetting and poor memory may have enuresis, which is commonly treated with medication, as prescribed by a physician. Enuresis is defined as incontinence that occurs in children older than 5 years of age when bedwetting occurs on average ≥2 times per week and persists for more than 6 months while they are asleep. When suffering from enuresis, it will affect the quality of the child’s sleep, which will lead to poor concentration, memory loss, slow reaction time during the day, and it will also have a certain impact on the psychological aspect of the child. Drug therapy commonly includes desmopressin, which is currently the recommended first-line drug for enuresis, especially for children with nocturnal polyuria. As well as anticholinergic drugs (such as oxybutynin, tolterodine, etc.), suitable for small bladder capacity or forced urinary muscle overactivity. However, other factors can not be completely ruled out caused by other factors, parents are advised to visit the patient in time to identify the cause, and medication should be administered in strict accordance with the doctor’s instructions in order to avoid adverse situations.