At present, clinically commonly used and relatively safe sleeping drugs are benzodiazepines, new non-benzodiazepines and other sedative-hypnotics, etc. The ten most commonly used relatively safe sleeping drugs are: I. Benzodiazepines (5 drugs) 1, fluzepam, chlordiazepoxide: are in the long-acting category; 2, estradiolam: these two are in the medium-acting category; 3, triazolam, oxazepam: these two belong to the short-acting category; these drugs Can produce central sedative effect by enhancing the function of the central nervous inhibitory neurotransmitter γ-aminobutyric acid. Generally with the increase of the dose, the sedative as well as hypnotic effect, can significantly shorten the time to fall asleep, significantly prolong the duration of sleep, reduce the number of awakenings; after the withdrawal of dependence and withdrawal symptoms are relatively mild. Second, the new non-benzodiazepine (4 drugs) 1, zolpidem: can selectively agonize γ-aminobutyric acid A receptor on the BZ1 receptor, thereby regulating the chloride channel, pharmacological effects similar to benzodiazepine, only for sedation and hypnosis; safety range, after-effects, tolerance, drug dependence and withdrawal symptoms are mild; 2, zopiclone: is a representative of the third generation of sedative-hypnotic drugs, with sedative effect; rapid effect, and effective up to 6 hours, can make patients achieve sufficient sleep depth, long-term use without significant drug resistance and withdrawal rebound phenomenon; 3, right zopiclone: is the right isomer of zopiclone, the effect is twice the parent, but the toxicity is only half of the parent; 4, zaleplon: belongs to the new non-benzodiazepine drugs, with sedative-hypnotic effect and good tolerance, long-term use almost no dependence. Long-term use is almost no dependence. Third, other sedative-hypnotic drugs (1 drug) chloral hydrate: used for persistent insomnia and for patients who do not respond well to other hypnotic drugs. These are the three main categories of ten relatively safe sedative drugs, recommended to be taken under the guidance of a doctor.