The health risks of diabetes are not caused by diabetes itself, but mainly by various diabetes comorbidities, including impotence (erectile dysfunction of the penis, ED), eye diseases, diabetic nephropathy, etc. Impotence (penile erectile dysfunction, ED) is one of the most common complications in diabetic patients, appearing early and occurring at a rate of up to 40%-60%, which is 3-5 times higher than that of non-diabetic patients, seriously affecting patients’ quality of life and family happiness. In addition, impotence is also an early warning symptom of diabetic comorbidity, and some studies have even taken impotence as an independent risk marker for cardiovascular events in diabetic patients. At present, the first line of clinical treatment for impotence is mainly “Viagra” drugs, such as sildenafil, tadalafil, vardenafil, etc. The clinical efficiency is nearly 70%, but the efficacy for patients with ED caused by diabetes, radical prostate cancer surgery, etc. is much lower than other types of ED. The latest study found that ED patients with varying degrees of penile erection after taking oral “Viagra” type drugs, with short-term extracorporeal low energy shock wave (LESW) treatment, the erectile function of the penis improved significantly, and most of the patients could get an erection and complete sexual intercourse on their own after stopping the “Viagra” type drugs. Most of the patients can have an erection and complete sexual intercourse on their own after stopping Viagra, and the effect can be sustained. A basic study found that LESW significantly improved erectile function in a diabetic rat model, and the mechanism may be related to the increase of smooth muscle cells and endothelial cells in the penile corpus cavernosum, upregulation of nNOS and VEGF expression, and downregulation of end-glucose metabolites (AGEs) receptor expression. Another study suggested that the mechanism of low-energy shock wave to improve diabetic impotence may also be related to the activation of endogenous stem cells in penis. Currently, the European Society of Urology “Guidelines for Male Sexual Dysfunction” recommends low-energy shockwave as the first line of treatment for impotence.