Sitting for a long time knee pain, consider and muscle fatigue, chondromalacia patella, osteoarthritis, etc., can take medication or physical therapy for the cause of the disease. 1. Muscle fatigue: you can massage the muscles around the knee joint to relax the local muscles, you can also apply hot compresses to improve local blood circulation to relieve pain, and apply diclofenac diethylamine cream. 2. Chondromalacia patella: you can do the action of hooking the foot and lifting the leg straight, oral glucosamine sulfate capsule or joint injection of sodium vitrate. 3. Osteoarthritis: oral non-steroidal painkillers, such as nimesulide dispersible tablets or diclofenac sodium extended-release tablets, can also be used externally flurbiprofen gel paste, the application of ultrasound physiotherapy. Sitting for a long time knee pain, it is recommended that timely medical treatment, under the guidance of the doctor for treatment.