After acute pyelonephritis is cured, blood creatinine will usually return to normal. Acute pyelonephritis can occur in all age groups and is most common in women of childbearing age. Clinical manifestations are related to the degree of infection, and the onset of the disease is usually more acute. There may be systemic symptoms such as fever, chills, nausea, vomiting, etc., urinary symptoms such as urinary frequency, urinary urgency, urinary pain, and lumbago, etc.; if the infection is more serious, it may lead to a decrease in the glomerular filtration rate, which will be manifested as an increase in blood creatinine. Generally after active anti-infective treatment, the disease can be cured, the drug can follow the doctor’s advice to choose levofloxacin, ceftazidime and so on. When the disease is cured, the blood creatinine may generally return to normal. The application of the above drugs have certain risks, patients need to get the guidance of specialists. Patients with acute pyelonephritis are advised to consult regular hospitals and receive standardized treatment under the guidance of physicians to avoid delays.