Skin ulceration after using imiquimod cream, first stop using the drug, local routine disinfection, with the promotion of mucosal repair of drug treatment. 1. Stop using the drug: the skin ulcers after using the drug, may be an adverse drug reaction, you should stop using it in time, and use running water to rinse, keep the wound clean and hygienic. 2. Local routine disinfection: you can use povidone-iodine to disinfect the ulcerated area, as well as the surrounding skin, to prevent infection. 3. Drugs to repair the mucosa: such as recombinant growth factor gel, rehabilitation of new liquid and other drugs. If there is secondary infection, you can work with antibiotic ointment such as erythromycin ointment and mupirocin ointment. It is recommended to go to the hospital for examination first, and the drugs need to be used under the guidance of professional doctors.