The causes of high cholesterol and high triglycerides are related to genetic factors, dietary factors, obesity, disease states, and alcohol consumption. 1. Genetic factors: Mutations in genes related to lipid metabolism can lead to a decrease in the activity of lipoprotein degrading enzymes, and defects in the structure or receptors of lipoproteins, which can reduce the clearance of lipoproteins in the body or slow down the decomposition and metabolism of lipoproteins; or increase the synthesis of lipoproteins, which can affect the absorption of fats in the diet, and so on, and lead to various types of primary hyperlipidemia. 2. Dietary factors: These are common non-pathological factors that cause hyperlipidemia. The absorption of lipids from the gastrointestinal tract increases greatly, promoting the occurrence of hyperlipidemia. 3. Obesity: weight gain promotes hepatic synthesis of apolipoprotein B, which increases low-density lipoprotein production; on the other hand, it promotes hepatic cholesterol synthesis. 4. Disease state: There are many diseases that cause dyslipidemia, commonly found in diabetes mellitus, nephrotic syndrome, hypothyroidism, gout, obstructive hepatic and biliary diseases, pancreatitis, systemic lupus erythematosus, gluconeogenesis, myeloma, acute porphyria, polycystic ovary syndrome and so on. 5. Long-term heavy drinking: can inhibit fatty acid oxidation in the liver and increase fatty acid synthesis. There are a variety of possible causes of dyslipidemia, patients need to pay attention, timely medical treatment, under the guidance of the doctor to use drugs.