If the blisters are small, they can be disinfected regularly with iodophor every day, and the blisters can be absorbed and the wound healed after 3~5 days; if the blisters are large, the blisters need to be punctured and the vesicular fluid in them should be removed cleanly, and then anti-infective drugs should be applied. For smaller blisters, you can usually apply povidone-iodine on the surface or use lidocaine chlorhexidine aerosol to disinfect the blisters, disinfect 2~3 times a day, and the blisters can be self-absorbed and the wounds healed in 3~5 days, and at the same time, you should pay attention to resting your feet, walking less, and avoiding further localized friction, irritation, and injury. As for larger blisters with more obvious pain, they can be sterilized with iodophor or lidocaine chlorhexidine aerosol first, and then by the doctor using a sterile syringe, the blister fluid will be suctioned and cleared, and finally anti-infection treatment with erythromycin ointment and fusidic acid cream. Meanwhile, attention should be paid to keep the wound clean and dry to avoid secondary bacterial infection. Patients with abraded blisters on the feet, if the blisters are large in size, it is recommended to consult a doctor as soon as possible for treatment.